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Article

Detection and functional resolution of soluble multimeric immune complexes by a comprehensive FcγR reporter cell panel

2020-11-11

Abstract excerpt

Fc-gamma receptor (FcγR) activation by soluble IgG immune complexes (sICs) represents a major mechanism of inflammation in certain autoimmune diseases such as systemic lupus erythematosus (SLE). A robust and scalable test system allowing for the detection and quantification of sIC bioactivity is missing. Previously described FcγR interaction assays are limited to certain FcγRs, lack scalability and flexibility, ar...

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Identifiers and source

Literature Corpus work
c84e224d-063d-59bc-8314-e19242f7aa9b
DOI
10.1101/2020.11.11.378232
Open publication

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Detection and functional resolution of soluble multimeric immune complexes by a comprehensive FcγR reporter cell panelDOI 10.1101/2020.11.11.378232
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