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Mutant Calreticulin in the Myeloproliferative Neoplasms

15 Jan 2020

Abstract excerpt

Abstract Mutations in the gene for calreticulin (CALR) were identified in the myeloproliferative neoplasms (MPNs) essential thrombocythaemia (ET) and primary myelofibrosis (MF) in 2013; in combination with previously described mutations in JAK2 and MPL, driver mutations have now been described for the majority of MPN patients. In subsequent years, researchers have begun to unravel the mechanisms by which mutant...

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PMID: 32382708
DOI: 10.1097/hs9.0000000000000333

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