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Analysis of <i>Treponema pallidum</i> strains from China using improved methods for whole-genome sequencing from primary syphilis chancres

2020-04-15

Abstract excerpt

<h4>ABSTRACT</h4> Whole-genome sequencing (WGS) of Treponema pallidum subsp. pallidum (TPA) has been constrained by the lack of in vitro cultivation methods for isolating spirochetes from patient samples. We built upon recently developed enrichment methods to sequence TPA directly from primary syphilis chancre swabs collected in Guangzhou, China. By combining parallel, pooled whole-genome amplification (ppWGA)...

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Literature Corpus work
ae2714cc-23bb-554d-86d9-b45d285825fe
DOI
10.1101/2020.04.15.043992
Open publication

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Analysis of <i>Treponema pallidum</i> strains from China using improved methods for whole-genome sequencing from primary syphilis chancresDOI 10.1101/2020.04.15.043992
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