Article

Genetic Engineering of <i>Treponema pallidum</i> subsp. <i>pallidum</i> , the Syphilis Spirochete

2021-05-07

Abstract excerpt

<h4>Background</h4> Despite more than a century of research, genetic manipulation of Treponema pallidum subsp. pallidum ( T. pallidum ), the causative agent of syphilis, has not been successful. The lack of genetic engineering tools has severely limited understanding of the mechanisms behind T. pallidum success as a pathogen. A recently described method for in vitro cultivation of T. pallidum, however, has...

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Literature Corpus work: 36743a8d-ac5c-5cc8-8818-52630ccb1638
DOI: 10.1101/2021.05.07.443079

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