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Phylogenetic and genetic characterization of Treponema pallidum strains from syphilis patients in Japan by whole-genome sequence analysis from global perspectives.

Scientific reports - 4 Feb 2021

Nishiki Shingo, Lee Kenichi, Kanai Mizue, Nakayama Shu-Ichi, Ohnishi Makoto

Abstract excerpt

Japan has had a substantial increase in syphilis cases since 2013. However, research on the genomic features of the Treponema pallidum subspecies pallidum (TPA) strains from these cases has been limited. Here, we elucidated the genetic variations and relationships between TPA strains in Japan (detected between 2014 and 2018) and other countries by whole-genome sequencing and phylogenetic analyses, including...

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PMID: 33542273
DOI: 10.1038/s41598-021-82337-7
PMCID: PMC7862685

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