Article
Sequencing of Treponema pallidum subsp. pallidum from isolate UZ1974 using Anti-Treponemal Antibodies Enrichment: First complete whole genome sequence obtained directly from human clinical material.
PloS one - 1 Jan 2018
Grillová Linda, Giacani Lorenzo, Mikalová Lenka, Strouhal Michal, Strnadel Radim, Marra Christina, Centurion-Lara Arturo, Poveda Lucy, Russo Giancarlo, Čejková Darina, Vašků Vladimír, Oppelt Jan, Šmajs David
Abstract excerpt
Treponema pallidum subsp. pallidum (TPA) is the infectious agent of syphilis, a disease that infects more than 5 million people annually. Since TPA is an uncultivable bacterium, most of the information on TPA genetics comes from genome sequencing and molecular typing studies. This study presents the first complete TPA genome (without sequencing gaps) of clinical isolate (UZ1974), which was obtained directly from...
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