Article

Comparative Genomics and Full-Length TprK Profiling of <i>Treponema pallidum</i> subsp. <i>pallidum</i> Reinfection

2019-11-13

Abstract excerpt

Developing a vaccine against Treponema pallidum subspecies pallidum , the causative agent of syphilis, remains a public health priority. Syphilis vaccine design efforts have been complicated by lack of an in vitro T. pallidum culture system, prolific antigenic variation in outer membrane protein TprK, and lack of functional annotation for nearly half of the genes. Understanding the genetic basis of T. pallidum...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 16d1090b-ca6a-59d8-a9d3-dff63f14ddf6
DOI: 10.1101/841395

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Comparative Genomics and Full-Length TprK Profiling of <i>Treponema pallidum</i> subsp. <i>pallidum</i> ReinfectionDOI 10.1101/841395Read

Comparative genomics and full-length Tprk profiling of Treponema pallidum subsp. pallidum reinfection.Semantic proximity Read

Estimation of Full-Length TprK Diversity in <i>Treponema pallidum</i> subspecies <i>pallidum</i>Semantic proximity Read

Estimation of Full-Length TprK Diversity in Treponema pallidum subsp. pallidumSemantic proximity Read

Insights into the mysterious genetic variation profile of <i>tprK</i> in <i>Treponema pallidum</i> under the development of natural human syphilis infectionSemantic proximity Read

Genome sequencing of 196 <i>Treponema pallidum</i> strains from six continents reveals additional variability in vaccine candidate genes and dominance of Nichols clade strains in MadagascarSemantic proximity Read

Profile of the <i>tprK</i> gene in primary syphilis patients based on next-generation sequencingSemantic proximity Read

<i>Treponema pallidum</i> subsp. <i>pallidum</i> genetic population structure and relevance to syphilis prevention and treatmentSemantic proximity Read

Sequence variation of rare outer membrane protein β-barrel domains in clinical strains provides insights into the evolution of <i>Treponema pallidum</i> subsp. <i>pallidum</i> , the syphilis spirocheteSemantic proximity Read

Longitudinal accumulation of <i>in vivo</i> and <i>in vitro-</i> grown <i>Treponema pallidum</i> subsp. <i>pallidum</i> TprK variants in the presence and absence of immune pressureSemantic proximity Read

Genomic epidemiology of <i>Treponema pallidum</i> and circulation of strains with diminished <i>tprK</i> antigen variation capability in Seattle, 2021-2022Semantic proximity Read

Clinical and genomic diversity of<i>Treponema pallidum subsp. pallidum:</i>A global, multi-center study of early syphilis to inform vaccine researchSemantic proximity Read

Contemporary syphilis is characterised by rapid global spread of pandemic<i>Treponema pallidum</i>lineagesSemantic proximity Read