Article

<i>Inseparable/IER3IP1</i> are essential for cytokinesis in <i>Drosophila</i> neuroblast and human cells

2024-07-23

Abstract excerpt

To unveil the molecular players that maintain neural stem cell homeostasis, we conducted a genetic screen in Drosophila and isolated an uncharacterized gene that we named Inseparable ( Insep ). Insep is the Drosophila homologue of human IER3IP1 , a gene associated with Microcephaly, Epilepsy, and Neonatal Diabetes Syndrome (MEDS-1). We show that Insep loss leads to early larval lethality with small brains a...

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Literature Corpus work: ae125816-217d-542e-aaca-ed31de287f17
DOI: 10.1101/2024.07.20.604396

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