Article
Human ectodermal organoids reveal the cellular origin of DiGeorge Syndrome
2025-08-08
Abstract excerpt
Neurocristopathies account for half of all birth defects and several cancers highlighting the need to understand early neural crest (NC) development, for which suitable human models don’t exist. Here, we present a pluripotent-stem-cell-based 3D ectodermal organoid model that faithfully recapitulates early ectodermal patterning of future central nervous system, epidermis and cranial and trunk NC, as well as a diver...
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Identifiers and source
- Literature Corpus work
- f8c733f1-193c-59a3-a3ee-a61a95001bfc
- DOI
- 10.1101/2025.08.08.669417