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Article

Essential requirement for IER3IP1 in B cell development.

Proceedings of the National Academy of Sciences of the United States of America - 14 Nov 2023

Zhong Xue, Moresco James J, Keller Katie, Lazaro Danielle Renee, Ely Claire, Moresco Eva Marie Y, Beutler Bruce, Choi Jin Huk

Abstract excerpt

In a forward genetic screen of mice with N-ethyl-N-nitrosourea-induced mutations for aberrant immune function, we identified animals with low percentages of B220+ cells in the peripheral blood. The causative mutation was in Ier3ip1, encoding immediate early response 3 interacting protein 1 (IER3IP1), an endoplasmic reticulum membrane protein mutated in an autosomal recessive neurodevelopmental disorder termed...

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Identifiers

PMID: 37934820
DOI: 10.1073/pnas.2312810120
PMCID: PMC10655558

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Essential requirement for IER3IP1 in B cell development.PMID 37934820Read ↗

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