Article

Mode of T cell priming durably shapes the TCR repertoire, effector function and α4β1 integrin expression of human virus-specific CD4 + T cells

2026-08-19

Abstract excerpt

The generation of an effective T cell response against an antigen depends on the recognition of the antigen by the T cell receptor (TCR), followed by T cell priming, initiating coordinated biophysical, biochemical and proliferative changes that drive differentiation into effector and memory clones. The immunological environments in which priming occurs, such as natural infection or vaccination, influences the qual...

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Literature Corpus work: ae02094a-7de1-58cb-9ec6-287d1132385f
DOI: 10.64898/2026.08.18.745226

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Mode of T cell priming durably shapes the TCR repertoire, effector function and α4β1 integrin expression of human virus-specific CD4 <sup>+</sup> T cells

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