SARS-CoV-2 antigen exposure history shapes phenotypes and specificity of memory CD8+ T cells.

doi:10.1038/s41590-022-01184-4

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Article

SARS-CoV-2 antigen exposure history shapes phenotypes and specificity of memory CD8+ T cells.

Nature immunology - 1 May 2022

Minervina Anastasia A, Pogorelyy Mikhail V, Kirk Allison M, Crawford Jeremy Chase, Allen E Kaitlynn, Chou Ching-Heng, Mettelman Robert C, Allison Kim J, Lin Chun-Yang, Brice David C, Zhu Xun, Vegesana Kasi, Wu Gang, Trivedi Sanchit, Kottapalli Pratibha, Darnell Daniel, McNeely Suzanne, Olsen Scott R, Schultz-Cherry Stacey, Estepp Jeremie H, McGargill Maureen A, Wolf Joshua, Thomas Paul G

Abstract excerpt

Although mRNA vaccine efficacy against severe coronavirus disease 2019 remains high, variant emergence has prompted booster immunizations. However, the effects of repeated exposures to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antigens on memory T cells are poorly understood. Here, we utilize major histocompatibility complex multimers with single-cell RNA sequencing to profile...

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Identifiers

PMID: 35383307
DOI: 10.1038/s41590-022-01184-4
PMCID: PMC9106845

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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