Article

Clonal dissection of immunodominance and cross-reactivity of the CD4 <sup>+</sup> T cell response to SARS-CoV-2

2021-03-23

Abstract excerpt

The identification of CD4 + T cell epitopes is essential for the design of effective vaccines capable of inducing neutralizing antibodies and long-term immunity. Here we demonstrate in COVID-19 patients a robust CD4 + T cell response to naturally processed SARS-CoV-2 Spike and Nucleoprotein, including effector, helper and memory T cells. By characterizing 2,943 Spike-reactive T cell clones, we found that 34% of...

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Literature Corpus work: cf20e5e6-01ed-56ac-918b-48cd9ba1f080
DOI: 10.1101/2021.03.23.436642

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