CD4+ T cells exhibit distinct transcriptional phenotypes in the lymph nodes and blood following mRNA vaccination in humans.

doi:10.1038/s41590-024-01888-9

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Article

CD4+ T cells exhibit distinct transcriptional phenotypes in the lymph nodes and blood following mRNA vaccination in humans.

Nature immunology - 1 Sept 2024

Borcherding Nicholas, Kim Wooseob, Quinn Michael, Han Fangjie, Zhou Julian Q, Sturtz Alexandria J, Schmitz Aaron J, Lei Tingting, Schattgen Stefan A, Klebert Michael K, Suessen Teresa, Middleton William D, Goss Charles W, Liu Chang, Crawford Jeremy Chase, Thomas Paul G, Teefey Sharlene A, Presti Rachel M, O'Halloran Jane A, Turner Jackson S, Ellebedy Ali H, Mudd Philip A

Abstract excerpt

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and mRNA vaccination induce robust CD4+ T cell responses. Using single-cell transcriptomics, here, we evaluated CD4+ T cells specific for the SARS-CoV-2 spike protein in the blood and draining lymph nodes (dLNs) of individuals 3 months and 6 months after vaccination with the BNT162b2 mRNA vaccine. We analyzed 1,277 spike-specific CD4+ T cells,...

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PMID: 39164479
DOI: 10.1038/s41590-024-01888-9
PMCID: PMC11627549

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