Article

Hypoxia inducible factors regulate Pneumovirus replication by enhancing innate immune sensing

2025-08-12

Abstract excerpt

<h4>ABSTRACT</h4> The immune mechanisms responsible for protection and pathogenesis in pneumoviral infection are not well defined. We demonstrated that pharmacological activation of the hypoxic inducible factor (HIF) signalling axis using Daprodustat limited viral replication through enhanced immune signalling. Transcriptomic analysis revealed HIF augmented activation of innate immune response genes, including in...

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Literature Corpus work: ae01f234-dfab-591f-9606-fe562e9b39a6
DOI: 10.1101/2025.08.12.669926

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