Article

Hypoxia inducible factors regulate infectious SARS-CoV-2, epithelial damage and respiratory symptoms in a hamster COVID-19 model

2022-03-15

Abstract excerpt

<h4>ABSTRACT</h4> Understanding the host pathways that define susceptibility to SARS-CoV-2 infection and disease are essential for the design of new therapies. Oxygen levels in the microenvironment define the transcriptional landscape, however the influence of hypoxia on virus replication and disease in animal models is not well understood. In this study, we identify a role for the hypoxic inducible factor (HIF)...

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Literature Corpus work: 1e818287-8b91-5fd5-ab52-e93d04f919f5
DOI: 10.1101/2022.03.15.484379

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