Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A Balancing Act: MDA5 in Antiviral Immunity and Autoinflammation.

Trends in microbiology - 1 Jan 2019

Dias Junior Antonio Gregorio, Sampaio Natalia G, Rehwinkel Jan

Abstract excerpt

Induction of interferons during viral infection is mediated by cellular proteins that recognise viral nucleic acids. MDA5 is one such sensor of virus presence and is activated by RNA. MDA5 is required for immunity against several classes of viruses, including picornaviruses. Recent work showed that mutations in the IFIH1 gene, encoding MDA5, lead to interferon-driven autoinflammatory diseases. Together with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Hereditary Autoinflammatory Diseases
Share to Immunity, Innate
Share to Interferon-Induced Helicase, IFIH1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutation

Share to Receptors, Immunologic

Share to RNA, Viral

Share to Virus Diseases

Source

Open in PubMed Open full text

Identifiers

PMID: 30201512
DOI: 10.1016/j.tim.2018.08.007
PMCID: PMC6319154

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A Balancing Act: MDA5 in Antiviral Immunity and Autoinflammation.PMID 30201512Read ↗

Autoimmune disorders associated with gain of function of the intracellular sensor MDA5.Semantic proximity Read ↗

SLIRP promotes autoimmune diseases by amplifying antiviral signaling via positive feedback regulationSemantic proximity Read ↗

Effects of type 1 diabetes-associated IFIH1 polymorphisms on MDA5 function and expression.Semantic proximity Read ↗

MDA5 autoimmune disease variant M854K prevents ATP-dependent structural discrimination of viral and cellular RNASemantic proximity Read ↗

Molecular basis of autoimmune disease protection by MDA5 variantsSemantic proximity Read ↗

Innate Viral Sensor MDA5 and Coxsackievirus Interplay in Type 1 Diabetes DevelopmentSemantic proximity Read ↗

IFIH1 loss of function predisposes to inflammatory and SARS-CoV-2-related infectious diseases.Semantic proximity Read ↗

Antiviral defense: interferons and beyondSemantic proximity Read ↗

MDA5 and autoimmune diseaseSemantic proximity Read ↗

ADAR1 haploinsufficiency and sustained viral RdRp dsRNA synthesis synergize to dysregulate RNA editing and cause multi-system interferonopathySemantic proximity Read ↗

<i>IFIH1</i>loss-of-function predisposes to inflammatory and SARS-CoV-2-related infectious diseasesSemantic proximity Read ↗

Reduced expression of the MDA5 Gene IFIH1 prevents autoimmune diabetes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.