Article

Mechanisms of ATM Inhibitor AZD1390-Mediated Radiosensitization by Comparing DNA DSB Formation and Repair in 4T1 Cells

2025-07-31

Abstract excerpt

Radioresistant cancers often exhibit upregulated DNA damage response (DDR) proteins including ataxia telangiectasia mutated (ATM), recovering more readily from radiation-induced DNA double-strand breaks (DSBs). ATM inhibitors (ATMi) are therefore being explored as adjuvants in radiotherapy to both enhance radiosensitivity and minimise normal tissue complications. The molecule AZD1390 has been developed as an inhib...

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Literature Corpus work: adf40d3e-f92b-5fdf-955d-b16adbf1b3f7
DOI: 10.1101/2025.07.27.667090

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Mechanisms of ATM Inhibitor AZD1390-Mediated Radiosensitization by Comparing DNA DSB Formation and Repair in 4T1 CellsDOI 10.1101/2025.07.27.667090Read

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