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Selective ATM inhibition augments radiation-induced inflammatory signaling and cancer cell death

17 Jan 2023

Abstract excerpt

Over half of all cancer patients undergo radiation therapy but there is an unmet need for more efficacious combination strategies with molecular targeted drugs. DNA damage response has emerged as an important intervention point for improving anti-tumor effects of radiation and several inhibitors are currently in development. Ataxia telangiectasia mutated (ATM) kinase is a key regulator of cellular response to DNA...

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Share to DNA Repair Mechanisms
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PMID: 36656721
DOI: 10.18632/aging.204487

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