Article

Mapping Isoform Abundance and Interactome of the Endogenous TMPRSS2-ERG Fusion Protein with Orthogonal Immunoprecipitation-Mass Spectrometry Assays

2020-09-24

Abstract excerpt

<h4>Summary</h4> TMPRSS2-ERG gene fusion, a molecular alteration driving nearly a half of prostate cancer cases, has been intensively characterized at the transcript level, while limited studies explored the molecular identity and function of the endogenous fusion at the protein level. Here, we developed and applied immunoprecipitation-mass spectrometry (IP-MS) assays for the measurement of a low-abundance T1E4 T...

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Literature Corpus work: adf3054f-450f-5221-9dab-8714a6e5a50e
DOI: 10.1101/2020.09.23.309088

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