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Article

Mapping Isoform Abundance and Interactome of the Endogenous TMPRSS2-ERG Fusion Protein by Orthogonal Immunoprecipitation–Mass Spectrometry Assays

1 Jan 2021

Abstract excerpt

TMPRSS2-ERG gene fusion, a molecular alteration found in nearly half of primary prostate cancer cases, has been intensively characterized at the transcript level. However limited studies have explored the molecular identity and function of the endogenous fusion at the protein level. Here, we developed immunoprecipitation-mass spectrometry assays for the measurement of a low-abundance T1E4 TMPRSS2-ERG fusion...

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Genomics and Chromatin Dynamics
Prostate Cancer Treatment and Research
Protein Degradation and Inhibitors

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 33771697
DOI: 10.1016/j.mcpro.2021.100075

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Mapping Isoform Abundance and Interactome of the Endogenous TMPRSS2-ERG Fusion Protein by Orthogonal Immunoprecipitation–Mass Spectrometry AssaysPMID 33771697Read ↗

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