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Article

Delineation of <i>TMPRSS2-ERG</i> Splice Variants in Prostate Cancer

1 Aug 2008

Abstract excerpt

PURPOSE: The expression of the ETS-related gene (ERG) is low or undetectable in benign prostate epithelial cells. High prevalence of ERG overexpression in prostate cancer cells due to TMPRSS2-ERG fusions suggest for causal roles of ERG protein in the neoplastic process. TMPRSS2-ERG fusion junctions have been extensively studied in prostate cancer. However, virtually nothing is known about the nature of...

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PMID: 18676740
DOI: 10.1158/1078-0432.ccr-08-0531

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