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Article

Replicative DNA polymerase mutations in cancer.

Current opinion in genetics & development - 1 Feb 2014

Heitzer Ellen, Tomlinson Ian

Abstract excerpt

Three DNA polymerases - Pol α, Pol δ and Pol ɛ - are essential for DNA replication. After initiation of DNA synthesis by Pol α, Pol δ or Pol ɛ take over on the lagging and leading strand respectively. Pol δ and Pol ɛ perform the bulk of replication with very high fidelity, which is ensured by Watson-Crick base pairing and 3'exonuclease (proofreading) activity. Yeast models have shown that mutations in the...

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Share to Cancer Genomics and Diagnostics
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24583393
DOI: 10.1016/j.gde.2013.12.005
PMCID: PMC4003352

Genes

POLE
POLD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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