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Article

Comprehensive Analysis of Human Colorectal Cancers Harboring Polymerase Epsilon Mutations.

International journal of molecular sciences - 25 Jul 2025

Gibson Louis M, Konda Phanithan, Bliss Hunter J, Nelakurti Devi D, Mirzaei Golrokh, Bouley Renee A, Wang Jing J, Petreaca Ruben C

Abstract excerpt

DNA polymerase epsilon (POLe) is the leading strand replicative polymerase. POLe mutations located primarily in the proofreading domain cause replication errors and increase mutation burden in cancer cells. Consequently, POLe has been classified as a cancer driver gene. Certain POLe frameshift mutations that affect the proofreading domain are purified in cancer cells, but point mutations in other domains have...

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Identifiers

PMID: 40806338
DOI: 10.3390/ijms26157208
PMCID: PMC12347369

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Comprehensive Analysis of Human Colorectal Cancers Harboring Polymerase Epsilon Mutations.PMID 40806338Read ↗

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