Article

A nuclear role for the contractile protein troponin I/UNC-27 in regulating muscle aging in <i>C. elegans</i>

2026-08-10

Abstract excerpt

Muscle ageing is characterized by evolutionarily conserved subcellular alterations across diverse organisms. In Caenorhabditis elegans , the decline in sarcomeric gene expression is among the earliest detectable ageing-associated changes, emerging at the onset of adulthood. To identify causal regulators of muscle ageing in an unbiased manner, we developed a genetic screening strategy that enables visual monitorin...

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Literature Corpus work: addb3451-d800-5cd3-a053-4f1aa5530ab9
DOI: 10.64898/2026.08.08.743652

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