Age-dependent Lamin remodeling induces cardiac dysfunction via dysregulation of cardiac transcriptional programs

Abstract excerpt

<title>Abstract</title> <p>As we age, structural changes contribute to progressive decline in organ function, which in the heart acts through poorly characterized mechanisms. Utilizing the rapidly aging fruit fly model with its significant homology to the human cardiac proteome, we found that cardiomyocytes exhibit progressive loss of Lamin C (mammalian Lamin A/C homologue) with age. Unlike other tissues and lami...

Topics

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• Arrhythmias, Cardiac
• Cardiomyopathies
• Cardiomyopathy, Dilated
• Death, Sudden, Cardiac
• Lamin Type A
• Mutation
• Myocytes, Cardiac
• Nuclear Structure and Function

Identifiers and source

Literature Corpus work

9c152350-863e-50e5-8b4e-9269305fedfb

DOI

10.21203/rs.3.rs-1021378/v1