Article
Disruption of Caenorhabditis elegans muscle structure and function caused by mutation of troponin I.
Biophysical journal - 1 Feb 2004
Burkeen A K, Maday S L, Rybicka K K, Sulcove J A, Ward J, Huang M M, Barstead R, Franzini-Armstrong C, Allen T StC
Abstract excerpt
Caenorhabditis elegans strains mutant for the unc-27 gene show abnormal locomotion and muscle structure. Experiments revealed that unc-27 is one of four C. elegans troponin I genes and that three mutant alleles truncate the protein: recessive and presumed null allele e155 terminates after nine codons; semidominant su142sd eliminates the inhibitory and C-terminal regions; and semidominant su195sd abbreviates the...
Topics
- Aging
- Amino Acid Sequence
- Animals
- Caenorhabditis elegans
- Molecular Sequence Data
- Movement Disorders
- Muscle, Skeletal
- Mutagenesis, Site-Directed
- Mutation
- Recombinant Proteins
- Sarcomeres
- Sequence Homology, Amino Acid
- Structure-Activity Relationship