Article
miR-1 coordinately regulates lysosomal v-ATPase and biogenesis to impact proteotoxicity and muscle function during aging.
eLife - 27 Jul 2021
Schiffer Isabelle, Gerisch Birgit, Kawamura Kazuto, Laboy Raymond, Hewitt Jennifer, Denzel Martin Sebastian, Mori Marcelo A, Vanapalli Siva, Shen Yidong, Symmons Orsolya, Antebi Adam
Abstract excerpt
Muscle function relies on the precise architecture of dynamic contractile elements, which must be fine-tuned to maintain motility throughout life. Muscle is also plastic, and remodeled in response to stress, growth, neural and metabolic inputs. The conserved muscle-enriched microRNA, miR-1, regulates distinct aspects of muscle development, but whether it plays a role during aging is unknown. Here we investigated...
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