Article

The autophagy initiating kinase ULK1 is required for pancreatic cancer cell growth and survival

2021-05-17

Abstract excerpt

Amongst cancer subtypes, pancreatic ductal adenocarcinoma (PDA) has been demonstrated to be most sensitive to autophagy inhibition, which may be due to unique metabolic rewiring in these cells. The serine/threonine kinase ULK1 forms the catalytic center of a complex mediating the first biochemical step of autophagy. ULK1 directly recieves signals from mTORC1 and AMPK to trigger autophagy under stress and nutrient...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: add542a4-186b-5276-be58-5167ac9a0db0
DOI: 10.1101/2021.05.15.444304

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The autophagy initiating kinase ULK1 is required for pancreatic cancer cell growth and survivalDOI 10.1101/2021.05.15.444304Read

ULK1 Knockout suppresses Pancreatic Cancer Progression by Inhibiting Autophagy and Enhancing Anti-tumor ImmunitySemantic proximity Read

Molecular Pathways Controlling Autophagy in Pancreatic CancerSemantic proximity Read

Mechanistic insights and therapeutic strategies for targeting autophagy in pancreatic ductal adenocarcinomaSemantic proximity Read

p53 status determines the role of autophagy in pancreatic tumour development.Semantic proximity Read

Structure and function of the ULK1 complex in autophagySemantic proximity Read

Autophagy as a therapeutic target in pancreatic cancerSemantic proximity Read

Lysosomal Storage Dysfunction, a Germline Variants Affecting Pancreatic Ductal Adenocarcinoma Development and ProgressionSemantic proximity Read

MDH1 and MPP7 Regulate Autophagy in Pancreatic Ductal AdenocarcinomaSemantic proximity Read

Lysosomal Storage Dysfunction, a Germline Variants Affecting Pancreatic Ductal Adenocarcinoma Development and ProgressionSemantic proximity Read

DYRK1A modulates c-MET in pancreatic ductal adenocarcinoma to drive tumour growthSemantic proximity Read

The phospholipid transporter PITPNC1 links KRAS to MYC to prevent autophagy in lung and pancreatic cancerSemantic proximity Read

Structure of the Human Autophagy Initiating Kinase ULK1 in Complex with Potent InhibitorsSemantic proximity Read