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Article

MDH1 and MPP7 Regulate Autophagy in Pancreatic Ductal Adenocarcinoma

14 Feb 2019

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDAC) is driven by metabolic changes in pancreatic cells caused by oncogenic mutations and dysregulation of p53. PDAC cell lines and PDAC-derived xenografts grow as a result of altered metabolic pathways, changes in stroma, and autophagy. Selective targeting and inhibition of one of these may open avenues for the development of new therapeutic strategies. In this study, we...

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Share to Autophagy in Disease and Therapy
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PMID: 30765601
DOI: 10.1158/0008-5472.can-18-2553

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