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Article

DYRK1A modulates c-MET in pancreatic ductal adenocarcinoma to drive tumour growth

20 Oct 2018

Abstract excerpt

Background and aims Pancreatic ductal adenocarcinoma (PDAC) is a very aggressive tumour with a poor prognosis using current treatments. Targeted therapies may offer a new avenue for more effective strategies. Dual-specificity tyrosine regulated kinase 1A (DYRK1A) is a pleiotropic kinase with contradictory roles in different tumours that is uncharacterised in PDAC. Here, we aimed to investigate the role of DYRK1A...

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PMID: 30343272
DOI: 10.1136/gutjnl-2018-316128

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