Article

Lysosomal Storage Dysfunction, a Germline Variants Affecting Pancreatic Ductal Adenocarcinoma Development and Progression

2023-02-23

Abstract excerpt

<h4>ABSTRACT</h4> Lysosome is closely linked to autophagy, which plays a vital role in pancreatic adenocarcinoma (PDAC) tumor biology. This study investigated whether lysosome storage dysfunction (LSD) contributes to PDAC development. Germline putative pathogenic variants (PPVs) in genes involved in lysosome functions were compared between PDAC patients (N=418) and healthy controls (N=845). Furthermore, Galc -knoc...

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Literature Corpus work: 8c7d0d81-1e30-5296-b2dc-dd94f1ebf728
DOI: 10.1101/2023.02.15.23286007

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