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Article

p53 status determines the role of autophagy in pancreatic tumour development.

Nature - 12 Dec 2013

Rosenfeldt Mathias T, O'Prey Jim, Morton Jennifer P, Nixon Colin, MacKay Gillian, Mrowinska Agata, Au Amy, Rai Taranjit Singh, Zheng Liang, Ridgway Rachel, Adams Peter D, Anderson Kurt I, Gottlieb Eyal, Sansom Owen J, Ryan Kevin M

Abstract excerpt

Macroautophagy (hereafter referred to as autophagy) is a process in which organelles termed autophagosomes deliver cytoplasmic constituents to lysosomes for degradation. Autophagy has a major role in cellular homeostasis and has been implicated in various forms of human disease. The role of autophagy in cancer seems to be complex, with reports indicating both pro-tumorigenic and tumour-suppressive roles. Here we...

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PMID: 24305049
DOI: 10.1038/nature12865

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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