Article

Human Puf-A, a Novel Component of 90S Pre-ribosome, Links Ribosome Biogenesis to Cancer Progression

2018-03-13

Abstract excerpt

We describe a novel biogenesis factor of the 90S pre-ribosome, Puf-A, which is a negative transcriptional target of p53. The expression of Puf-A is not only upregulated in advanced human lung cancer and tumors of patients especially with TP53 mutation, but also is highly prognostic for stage I lung cancer. Loss of Puf-A expression prevents Kras G12D /p53 -/- –induced tumor progression in the lungs and induces a...

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Literature Corpus work: adce15a1-62fd-5375-a5f8-03ee44fc621b
DOI: 10.1101/281857

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