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Cancer Biogenesis in Ribosomopathies

11 Mar 2019

Abstract excerpt

Ribosomopathies are congenital diseases with defects in ribosome assembly and are characterized by elevated cancer risks. Additionally, somatic mutations in ribosomal proteins have recently been linked to a variety of cancers. Despite a clear correlation between ribosome defects and cancer, the molecular mechanisms by which these defects promote tumorigenesis are unclear. In this review, we focus on the emerging...

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PMID: 30862070
DOI: 10.3390/cells8030229

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