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Article

Phosphorylation of PUF-A/PUM3 on Y259 modulates PUF-A stability and cell proliferation.

PloS one - 1 Jan 2021

Lin Hung-Wei, Lee Jin-Yu, Chou Nai-Lin, Shih Ting-Wei, Chang Mau-Sun

Abstract excerpt

Human PUF-A/PUM3 is a RNA and DNA binding protein participating in the nucleolar processing of 7S to 5.8S rRNA. The nucleolar localization of PUF-A redistributes to the nucleoplasm upon the exposure to genotoxic agents in cells. However, little is known regarding the roles of PUF-A in tumor progression. Phosphoprotein database analysis revealed that Y259 phosphorylation of PUF-A is the most prevalent residue...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34407138
DOI: 10.1371/journal.pone.0256282
PMCID: PMC8372891

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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