Article

An investigation of the role of the MDM2-NME interaction in cancer cells

2014-01-01

Abstract excerpt

MDM2 is a proto-oncogene well known for its role as a negative regulator of the p53 tumour suppressor. It has also been demonstrated that co-upregulation of MDM2 and wild-type p53 is linked with reduced disease specific survival in renal cell carcinoma (RCC). Moreover, MDM2 expression has been shown to promote cell motility and invasiveness in several cancer cell types including RCC cells in a p53- and RING-finger...

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Literature Corpus work: adab6cfe-2d15-5df6-9a66-f72dd3934cf7
DOI: 10.17638/02003899

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