Article

Microbial-associated acylated putrescines as immunomodulatory molecules in inflammatory bowel diseases

2026-08-25

Abstract excerpt

The gut microbiota regulates intestinal immunity through metabolite production, yet most disease-associated metabolites remain functionally uncharacterized. In inflammatory bowel diseases (IBD), where the microbial metabolome is profoundly altered, we identify N-acyl putrescines as microbiome-associated metabolites enriched across two independent cohorts. N-oleoylputrescine (NOP) emerges as the primary immunomodul...

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Literature Corpus work: ada30bba-6651-5727-b304-50ada154b3f9
DOI: 10.64898/2026.08.24.746719

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