Article

Gut microbiota phospholipids regulate intestinal gene expression and can counteract the effects of antibiotic treatment

2025-12-02

Abstract excerpt

<title>Abstract</title> <p>Early-life antibiotic exposure perturbs the developing gut microbiome and increases risk for immune disorders such as type 1 diabetes (T1D) in non-obese diabetic (NOD) mice. Comparing germ-free and conventional mice, we identified 747 intestinal lipid compounds and defined a subset of gut microbially-produced lipids (GMPLs). Antibiotic treatment disrupted GMPL profiles in mice and in hu...

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Literature Corpus work: 1e851369-bdf6-54a3-9783-a762fc17dce1
DOI: 10.21203/rs.3.rs-7924457/v1

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