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Uncovering de novo polyamine biosynthesis in the gut microbiome and its alteration in inflammatory bowel disease

9 Feb 2025

Abstract excerpt

Polyamines are important gut microbial metabolites known to affect host physiology, yet the mechanisms behind their microbial production remain incompletely understood. In this study, we developed a stable isotope-resolved metabolomic (SIRM) approach to track polyamine biosynthesis in the gut microbiome. Viable microbial cells were extracted from fresh human and mouse feces and incubated anaerobically with...

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PMID: 39924644
DOI: 10.1080/19490976.2025.2464225

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