Article

CDK4 or CDK6 upregulation induces DNA replication stress and genomic instability to cause EGFR targeted therapy resistance in lung cancer

2024-03-14

Abstract excerpt

Epidermal growth factor receptor (EGFR)–mutant lung adenocarcinomas (LUAD) harbor a complex landscape of genetic co-alterations and potential oncogenic interactions. Among them are recurrent amplifications of the cell cycle regulatory genes CDK4 and CDK6 , which have been clinically implicated in resistance to EGFR tyrosine kinase inhibitors (TKIs). However, the mechanisms by which CDK4/6 upregulation promotes t...

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Literature Corpus work: ad98d4b8-9601-59cd-b705-a079b585c929
DOI: 10.1101/2024.03.12.584638

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