Evolution and clinical impact of co-occurring genetic alterations in advanced-stage EGFR-mutant lung cancers.

doi:10.1038/ng.3990

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Article

Evolution and clinical impact of co-occurring genetic alterations in advanced-stage EGFR-mutant lung cancers.

Nature genetics - 1 Dec 2017

Blakely Collin M, Watkins Thomas B K, Wu Wei, Gini Beatrice, Chabon Jacob J, McCoach Caroline E, McGranahan Nicholas, Wilson Gareth A, Birkbak Nicolai J, Olivas Victor R, Rotow Julia, Maynard Ashley, Wang Victoria, Gubens Matthew A, Banks Kimberly C, Lanman Richard B, Caulin Aleah F, St John John, Cordero Anibal R, Giannikopoulos Petros, Simmons Andrew D, Mack Philip C, Gandara David R, Husain Hatim, Doebele Robert C, Riess Jonathan W, Diehn Maximilian, Swanton Charles, Bivona Trever G

Abstract excerpt

A widespread approach to modern cancer therapy is to identify a single oncogenic driver gene and target its mutant-protein product (for example, EGFR-inhibitor treatment in EGFR-mutant lung cancers). However, genetically driven resistance to targeted therapy limits patient survival. Through genomic analysis of 1,122 EGFR-mutant lung cancer cell-free DNA samples and whole-exome analysis of seven longitudinally...

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Identifiers

PMID: 29106415
DOI: 10.1038/ng.3990
PMCID: PMC5709185

Genes

EGFR
CDK4
CDK6
CTNNB1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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