Article
Genomic profiling of multiple sequentially acquired tumor metastatic sites from an "exceptional responder" lung adenocarcinoma patient reveals extensive genomic heterogeneity and novel somatic variants driving treatment response.
Cold Spring Harbor molecular case studies - 1 Nov 2016
Biswas Romi, Gao Shaojian, Cultraro Constance M, Maity Tapan K, Venugopalan Abhilash, Abdullaev Zied, Shaytan Alexey K, Carter Corey A, Thomas Anish, Rajan Arun, Song Young, Pitts Stephanie, Chen Kevin, Bass Sara, Boland Joseph, Hanada Ken-Ichi, Chen Jinqiu, Meltzer Paul S, Panchenko Anna R, Yang James C, Pack Svetlana, Giaccone Giuseppe, Schrump David S, Khan Javed, Guha Udayan
Abstract excerpt
We used next-generation sequencing to identify somatic alterations in multiple metastatic sites from an "exceptional responder" lung adenocarcinoma patient during his 7-yr course of ERBB2-directed therapies. The degree of heterogeneity was unprecedented, with ∼1% similarity between somatic alterations of the lung and lymph nodes. One novel translocation, PLAG1-ACTA2, present in both sites, up-regulated ACTA2...
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