Article

Effect of Dual Leucine Zipper Kinase Inhibitor GNE-3511 on Epileptogenesis and Cognitive and Behavioral Changes in a Temporal Lobe Epilepsy Model in Mice

2023-06-12

Abstract excerpt

Inflammation and neuronal loss are key factors in the pathophysiology of epilepsy. It is known that activation of Dual Leucine Zipper Kinase (DLK) in chronic neurodegenerative diseases causes neuron death and axon degeneration through apoptotic pathways. Genetic deletion of DLK (dual leucine zipper kinase, MAP3K12) or pharmacological inhibition by GNE-3511 or GNE-8505 was found to have benefits in mouse models of...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ad8ea7a9-c121-52b6-b939-6a2930451236
DOI: 10.1101/2023.06.11.544443

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Effect of Dual Leucine Zipper Kinase Inhibitor GNE-3511 on Epileptogenesis and Cognitive and Behavioral Changes in a Temporal Lobe Epilepsy Model in MiceDOI 10.1101/2023.06.11.544443Read

Inhibition of Death-associated Protein Kinase 1 protects against Epileptic Seizures in miceSemantic proximity Read

A novel AAV9-dual microRNA-vector targeting GRIK2 in the hippocampus as a treatment for mesial temporal lobe epilepsySemantic proximity Read

NLRP3 inflammasome inhibits mitophagy during the progression of temporal lobe epilepsySemantic proximity Read

IRAK4 in the hippocampus increases susceptibility to seizures through NF-κB/NLRP3-mediated neuronal pyroptosisSemantic proximity Read

GluK2 is a target for gene therapy in drug-resistant Temporal Lobe EpilepsySemantic proximity Read

GLS2 reduces the occurrence of epilepsy by affecting mitophagy function in mouse hippocampal neuronsSemantic proximity Read

Translatome analysis reveals cellular network in DLK-dependent hippocampal glutamatergic neuron degenerationSemantic proximity Read

Disease-modifying effects of sodium selenate in a model of drug-resistant, temporal lobe epilepsySemantic proximity Read

Neuroinflammation and progressive myoclonus epilepsies: from basic science to therapeutic opportunities.Semantic proximity Read

Guizhi Fuling capsule relieves memory deficits by inhibition of microglial neuroinflammation through blocking JAK2/STAT3 pathway in presenilin1/2 conditional double knockout miceSemantic proximity Read

Genistein Protects Epilepsy-Induced Brain Injury Through Regulating The JAK2/STAT3 and Keap1/Nrf2 Signaling Pathways in The Developing RatsSemantic proximity Read

Neuroinflammation: A Signature or a Cause of Epilepsy?Semantic proximity Read