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NLRP3 inflammasome inhibits mitophagy during the progression of temporal lobe epilepsy

10 May 2025

Abstract excerpt

Epilepsy is a neurological disorder involving mitochondrial dysfunction and neuroinflammation. This study examines the relationship between NLRP3 inflammasome activation and mitophagy in the temporal lobe epilepsy, which has not been reported before. A pilocarpine-induced epileptic rat model was used to assess seizure activity and neuronal loss. Pyroptosis markers (NLRP3, cleaved Gasdermin D, IL-1β/IL-18), and...

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PMID: 40348802
DOI: 10.1038/s41598-025-01087-y

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