Article

IRAK4 in the hippocampus increases susceptibility to seizures through NF-κB/NLRP3-mediated neuronal pyroptosis

2024-02-01

Abstract excerpt

<h4>Background: </h4> Interleukin-1 receptor-associated kinase 4 (IRAK4) plays an important role in immune modulation in various central nervous system disorders. Previous studies have found that the IRAK4 pathway is involved in lead-induced cell pyroptosis. However, there is no report on the role of IRAK4 in epilepsy models and its involvement in regulating cell pyroptosis in epilepsy, both in animal and clinical...

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Literature Corpus work: 8199b537-25c6-5fa2-9c76-1f4e8ac5b6f1
DOI: 10.21203/rs.3.rs-3912284/v1

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