BCR repertoire analysis and cloning of antibody candidates targeting native and Asp7-isomerized β-amyloid

Abstract excerpt

Computational approaches are increasingly used to predict monoclonal antibody (mAb) candidates from BCR-seq datasets. However, the reliable identification of B cells encoding antibodies against rare antigenic epitopes remains challenging. We employed a repertoire-guided workflow combining antigen-tetramer sorting of B cells from immunized mice, followed by low-input bulk BCR-seq yielding informative clonal reperto...

Topics

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• Antibodies
• Communicable Diseases
• HIV Research and Treatment
• Immune Cell Function and Interaction
• Immunotherapy and Immune Responses
• Monoclonal and Polyclonal Antibodies Research
• T-cell and B-cell Immunology
• vaccines and immunoinformatics approaches

Identifiers and source

Literature Corpus work

ad88b41d-65ad-57c2-8cc9-1470187f95e9

DOI

10.64898/2025.12.26.696595