Article

Focused framework sampling recovers binding-positive humanized anti-amyloid-β antibodies in a single sorting round

2026-08-15

Abstract excerpt

Therapeutic antibody development requires workflows that integrate antigen-reactive clone discovery with efficient humanization and early developability assessment. Here, we combined immune yeast fragment antigen-binding (Fab) display with single-round focused humanization and applied the workflow to antibodies against amyloid-beta (Abeta)-derived preparations. Immunization with Abeta1-42 aggregate preparations ge...

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Literature Corpus work: 8b0afd83-a53e-54b4-9328-d51e984ab9c8
DOI: 10.64898/2026.08.14.744767

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