Article
Novel Approaches to Analyze Immunoglobulin Repertoires.
Trends in immunology - 1 Jul 2017
Wardemann Hedda, Busse Christian E
Abstract excerpt
Analysis of immunoglobulin (Ig) repertoires aims to comprehend Ig diversity with the goal of predicting humoral immune responses in the context of infection, vaccination, autoimmunity, and malignancies. The first next-generation sequencing (NGS) analyses of bulk B cell populations dramatically advanced sampling depth over previous low-throughput single-cell-based protocols, albeit at the expense of accuracy and...
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