Article

Transcriptomic Profiling of High vs. Low Flow Regions of Mouse and Human Trabecular Meshwork

2026-07-24

Abstract excerpt

<h4>Purpose</h4> Aqueous humor outflow through the trabecular meshwork (TM) is segmental, demonstrating high flow (HF) and low flow (LF) regions. Here, we investigate transcriptomic differences between flow regions in naïve mouse and non-glaucomatous human TM tissue to better understand intraocular pressure (IOP) regulation. <h4>Methods</h4> Human eyes (<6 hours postmortem) from two donors were perfused with a f...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ad673b78-51c7-50dc-aac2-c944e1c412c6
DOI: 10.64898/2026.07.23.740307

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Transcriptomic Profiling of High vs. Low Flow Regions of Mouse and Human Trabecular MeshworkDOI 10.64898/2026.07.23.740307Read

Molecular taxonomy of human ocular outflow tissues defined by single cell transcriptomicsSemantic proximity Read

Molecular taxonomy of human ocular outflow tissues defined by single-cell transcriptomicsSemantic proximity Read

Transcriptomic Atlas of Human Trabecular Meshwork Uncovers the Cellular Landscape and Provides Insights into Glaucoma PathophysiologySemantic proximity Read

VEGFA-Positive Macrophages Regulate Aqueous Humor Outflow in Aged Mice and HumansSemantic proximity Read

Cell Atlas of Aqueous Humor Outflow Pathways in Eyes of Humans and Four Model Species Provides Insights into Glaucoma PathogenesisSemantic proximity Read

Cell atlas of aqueous humor outflow pathways in eyes of humans and four model species provides insight into glaucoma pathogenesisSemantic proximity Read

Leveraging single-cell transcriptomics of developing rat ocular outflow tissues to prioritize congenital glaucoma candidate genesSemantic proximity Read

Genome-wide transcriptome profiling of human trabecular meshwork cells treated with TGF-β2Semantic proximity Read

Single-cell transcriptomic Atlas of aging macaque ocular outflow tissuesSemantic proximity Read

Transcriptomic analysis of TGFβ-mediated fibrosis in primary human Tenon’s fibroblastsSemantic proximity Read

Genes expressed in the human trabecular meshwork during pressure‐induced homeostatic responseSemantic proximity Read

An Integrated muti-omics cell atlas of the human trabecular meshwork and ciliary bodySemantic proximity Read